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Komives presented a comprehensive review discussing the utility of HDX-MS in discovery of IDRs in proteins, monitoring coupled folding and binding, and characterization of protein aggregates and oligomers ( 2.13.2 Ion mobility-mass spectrometry (IM-MS) Ion mobility-mass spectrometry (IM-MS) is an analytical technique that separates ions based on their collision cross-section (CCS, which is a measure of the size and shape of ion that defines its collision rate) in the gas phase

In some embodiments, degradation of the therapeutic agent is reduced or eliminated through the use of specific pH ranges for buffer components and specific proportions of gelling agents in the formulations

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However, everyone's biochemistry is unique